After the Babylonians conquered the Israelites, the Ark of the covenant vanished from history.
Many, if not all religions, treasure relics. But it can be safely argued that no religious object (besides the Holy Grail, perhaps) has had an impact in popular culture as significant as that of the Ark of the Covenant.
Exodus 25 explains the Ark was to contain the tablets of the covenant law; namely, the Ten Commandments:












