Cathedral of Saint Mary of the Assumption (San Francisco, California)

Constructed in 1970, the Cathedral of Saint Mary of the Assumption is an example of modern Catholic architecture. The roof was designed with hyperbolic paraboloids, which allow the base of the roof to exist as a square that rises up to create a cross. St. Mary's roof rises to about 190 feet, but the cross atop it stands 55 feet tall.

Mission San Xavier del Bac (Tuscon, Arizona)

Since it was completed in 1797, this Spanish-style Catholic church has needed practically constant renovation. The east tower was never completed due to budget restrictions. The church is known for an elaborate carved facade that surrounds the front doors. As it was built before the Arizona territory was officially part of the US, San Xavier is technically the oldest European structure in the state.

United States Air Force Academy Cadet Chapel (Colorado Springs, Colorado)

Not a Catholic church but one open to all denominations, the Air Force Academy Cadet Chapel is highly regarded for its modern architecture. The building features 17 spires that span its length. The design originally called for 21 spires, but it was reduced due to monetary restrictions. As this place of worship is owned by the US government, it contains spaces for people of all faiths to worship.

El Santuario de Chimayo (Chimayó, New Mexico)

Considered to be one of the most important pilgrimage sites in the US, El Santuario de Chimayo recieves over 300,000 pilgrims each year, with the majority of them coming during Holy Week. The tradition is to walk the entire pilgrimage, and some people come from nearly 100 miles away.

The Shrine of the Grotto of the Redemption (West Bend, Iowa)

A part of the Roman Catholic Diocese of Sioux Falls, this shrine is a made up of nine different grottoes, each one depicting a scene from the life of Christ. It was constructed primarily from rocks, minerals, and petrified wood. The shrine is constantly being added to, and it covers more than a full city block.

Chapel of the Holy Cross (Sedona, Arizona)

Inspired by the Empire State Building, the nondenominational Chapel of the Holy Cross was originally intended to be completed by Lloyd Wright, in Budapest. However when WWII broke out, the plans were taken back to Arizona, where it was completed in 1956. It is considered on of the Seven Man-Made Wonders of Arizona.

Shrine of Our Lady of La Leche (St. Augustine, Florida)

A monument to the devotion to Our Lady of La Leche (Our Lady of the Milk), which was brought to America by Spanish colonists in the 16th Century. The centerpiece is a statue of Mary nursing the infant Jesus, a replica of a Spanish statue. The shrine is a part of the Spanish Catholic Mission, Nombre de Dios (Name of God).

San Francisco de Asis Mission Church (Ranchos de Taos, New Mexico)

A large adobe structure, which almost looks more like a fort than a church, the St. Francis of Assisi Mission Church was built with the intention of providing a sanctuary for the congregation to withstand Comanche attacks in the 19th Century. It was famously the subject of several paintings by Georgia O'Keeffe.

St. Joseph the Betrothed Ukrainian Greek Catholic Church (Chicago, Illinois)

Considered an example of ultra-modern architectural design, it was constructed with thirteen golden domes. There are 12 smaller domes arranged around a much larger dome, representing the twelve apostles and Christ respectively.

The National Sanctuary of Our Sorrowful Mother (Portland, Oregon)

Also known simply as "The Grotto," The National Sanctuary of Our Sorrowful Mother was built into the side of a cliff. The grounds feature a church, a meditation hall, and thousands of feet of trails. These trails also feature Stations of the Cross and a botanical garden.

Christ Cathedral (Garden Grove, California)

Formerly known as the Crystal Cathedral, the property was acquired by the Diocese of Orange, renovated, and dedicated in 2019. When it was constructed, in 1981, it was considered the world's largest glass building.