The prayer from St. John Paul II asks St. Juan Diego to guide us to Our Lady of Guadalupe, who will in turn lead us to God.
While the image of Our Lady of Guadalupe has become a cultural icon, veneration of the Virgin Mary shouldn't stop there. The primary mission of Mary's apparition was to lead souls to her Son, Jesus Christ.
St. John Paul II prayed a short prayer at the canonization of St. Juan Diego that expresses this truth, praying that we may be led closer to God through her apparition.